Home HOME Neoplasma 2019 Neoplasma Vol.66, No.5, p.801–809, 2019

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.66, No.5, p.801–809, 2019

Title: Association between p53 protein phosphorylated at serine 20 expression and ovarian carcinoma stem cells phenotype: correlation with clinicopathological parameters of ovarian cancer
Author: J. Bar, P. Grelewski, I. Deszcz, L. Noga, L. Hirnle, A. Lis-Nawara

Abstract: Biological behavior of ovarian carcinomas might be the result of cellular diversity existing in tumor tissue, which consists of differentiated and undifferentiated cells showing stem cells biological properties and function. We examined correlation between p53 protein phosphorylated at serine 20 (p-p53(Ser20)) and CD133, SOX2, Notch1 expression, in order to reveal p-p53(Ser20) stemness function in ovarian cancer. p-p53(Ser20), CD133, Notch1, SOX2 expression was analyzed on 104 ovarian carcinomas using immunohistochemical staining. The positive correlation between p53 and p-p53(Ser20) (p=0.02), p53 and SOX2 (p=0.02), p-p53(Ser20) and Notch1 (p=0.03), p-p53(Ser20) and CD133 (p=0.01) expression was observed in ovarian carcinomas. The parallel expression of p-p53(Ser20)/CD133, p-p53(Ser20)/Notch1 reflecting co-expression of these proteins in single carcinoma cell, and p-p53(Ser20)/SOX2 expression was associated with advanced stage and p-p53(Ser20)/Notch1, p53/SOX2, p-p53(Ser20)/SOX2 parallel expression correlated with high tumor grade. The correlation between p-p53(Ser20) and CD133, Notch1, SOX2 expression and clinical parameters indicate, that malignancy and biological behavior of ovarian carcinomas depend on interaction between p-p53(Ser20) and carcinoma stem cells biomarkers expression.

Keywords: ovarian carcinoma, p53 phosphorylation, CSCs biomarkers expression
Published online: 30-Sep-2019
Year: 2019, Volume: 66, Issue: 5 Page From: 801, Page To: 809

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