Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.5, p.325–330, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.120, No.5, p.325–330, 2019

Title: SynCardia, total artificial heart, as a bridge to transplant
Author: M. Hulman, P. Artemiou, V. Hudec, I. Olejarova, E. Goncalvesova

Abstract: INTRODUCTION: Implantation of a total artificial heart is an alternative to durable biventricular assist device support in selected patients. We present our initial experience with the implantation of the SynCardia total artificial heart (TAH) in three patients. The first patient, was the first SynCardia (TAH) implantation in the Visegrad Four (V4) countries
METHOD: Three patients with severe refractory end stage biventricular heart failure listed for heart transplant were indicated for SynCardia TAH implantation
RESULTS: We present in details the perioperative and postoperative outcomes of these patients. The first and the third patient, after 195 and 126 days of TAH support respectively, had a successful heart transplants, the second patient died on 11th postoperative day. The cause of death was brain bleeding due to ruptured undiagnosed brain aneurysm.
CONCLUSION:  SynCardia TAH is an alternative therapy in patients with end-stage biventricular heart failure waiting for heart transplantation. The SynCardia TAH with pulsatility resembles the physiologic circulation, improves the condition of the patients and increases survival compared to the biventricular assist devices. It is an intermediate step until the development of genetically modified animal hearts, engineered bioartificial hearts or hearts from induced pluripotent stem cells that would replace the failing heart in the patients with end-stage heart disease (Tab. 2, Fig. 1, Ref. 27).

Keywords: biventricular heart failure, total artificial heart, Syncardia TAH, biventricular assist device, heart transplantation
Published online: 21-May-2019
Year: 2019, Volume: 120, Issue: 5 Page From: 325, Page To: 330
doi:10.4149/BLL_2019_053


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