Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.5, p.344–348, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.120, No.5, p.344–348, 2019

Title: The relationship between plasma microRNAs and serum trace elements levels in primary hyperlipidemia
Author: F. H. Yerlikaya, U. Can, M. S. Alpaydin, A. Aribas

Abstract: OBJECTIVES: The aim of the study was to investigate the relationship between plasma microRNA expression levels, which are associated with lipid metabolism and serum trace element levels in patients with primary hyperlipidemia.
METHODS: This study was performed on 46 (21M / 25F) primary hyperlipidemia patients aged 25–65 years and 37 (18 M/19 F) healthy people aged 25–65 years.
RESULTS: The following miRNAs were upregulated: miR-33a-5p, miR-370-5p, miR-378a-3p, miR-27a-3p, miR-27a-5p and miR-335-5p. Additionally, the levels of Co (p < 0.001), Ni (p < 0.01), Cd (p < 0.001) were significantly higher and the level of Cr (p < 0.01), Fe (p < 0.05), Mn (p < 0.01), Se (p < 0.001) and Mo (p < 0.001) was significantly lower in the primary hyperlipidemic patients compared to the healthy people . Also, miR-33a-5p was negatively correlated with serum Cr levels in patients with primary hyperlipidemia (r = –0.376, p < 0.05).
CONCLUSIONS: Our study demonstrates that miR-33a-5p and Cr element may regulate abnormal lipid homeostasis. Also, miR-370, miR-378, miR-27-a and miR-335 might aid in the identification of new therapies to treat patients with primary hyperlipidemia (Tab. 3, Ref. 36).

Keywords: primary hyperlipidemia, microRNA, trace elements
Published online: 21-May-2019
Year: 2019, Volume: 120, Issue: 5 Page From: 344, Page To: 348
doi:10.4149/BLL_2019_056


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