Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.5, p.372–379, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.120, No.5, p.372–379, 2019

Title: The effect of ferulic acid on experimental traumatic brain damage in rats
Author: G. Erbil, U. Sacik, F. Yilmaz, H. Kisaoglu, Z. Erbayraktar, C. Pekcetin, C. Ozogul

Abstract: AIM: Traumatic brain injury is an important social health problem due to the fact that young adults are more likely to be affected, and advanced functional limitations are observed in survivors. In this study, we aimed to investigate the protective effect of ferulic acid in an experimental trauma model.
MATERIAL AND METHODS: This study was performed in March 2016 at Dokuz Eylül University Experimental Animal Laboratory. Subjects were randomly divided into 4 groups Control, Ethyl Alcohol, Trauma, Trauma/Ferulic Acid groups. For histological findings, Cresyl violet; for immunohistochemical analysis, TUNEL and Active Caspase-3 staining were used. For biochemical analysis, Superoxide dismutase, Malondialdehyde, and Glutathione values ​​were examined.
RESULTS: The application of ferulic acid has been shown to primarily reduce neuronal apoptosis, the levels of free radicals, and to effect oxidant/antioxidant balance positively by increasing the levels of antioxidants, such as Superoxide dismutase and Glutathione that are developed due to brain damage. Our study group has shown that ferulic acid decreased nerve tissue pathologies after generated brain trauma compared to injury groups.
CONCLUSION: Addition of ferulic acid to the traditional head trauma treatment has the strength, and ability to increase the rate, and percentage of healing (Tab. 2, Fig. 4, Ref. 28).

Keywords: ferulic acid, head trauma, hippocampus, prefrontal cortex
Published online: 21-May-2019
Year: 2019, Volume: 120, Issue: 5 Page From: 372, Page To: 379
doi:10.4149/BLL_2019_061


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