Home 
HOME Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.5, p.372–379, 2019
HOME Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.5, p.372–379, 2019
Journal info
|
||||
Select Journal
Journals
Bratislava Medical Journal 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Bratislava Medical Journal Vol.120, No.5, p.372–379, 2019 |
||
| Title: The effect of ferulic acid on experimental traumatic brain damage in rats | ||
| Author: G. Erbil, U. Sacik, F. Yilmaz, H. Kisaoglu, Z. Erbayraktar, C. Pekcetin, C. Ozogul | ||
| Abstract: AIM: Traumatic brain injury is an important social health problem due to the fact that young adults are more likely to be affected, and advanced functional limitations are observed in survivors. In this study, we aimed to investigate the protective effect of ferulic acid in an experimental trauma model. MATERIAL AND METHODS: This study was performed in March 2016 at Dokuz Eylül University Experimental Animal Laboratory. Subjects were randomly divided into 4 groups Control, Ethyl Alcohol, Trauma, Trauma/Ferulic Acid groups. For histological findings, Cresyl violet; for immunohistochemical analysis, TUNEL and Active Caspase-3 staining were used. For biochemical analysis, Superoxide dismutase, Malondialdehyde, and Glutathione values were examined. RESULTS: The application of ferulic acid has been shown to primarily reduce neuronal apoptosis, the levels of free radicals, and to effect oxidant/antioxidant balance positively by increasing the levels of antioxidants, such as Superoxide dismutase and Glutathione that are developed due to brain damage. Our study group has shown that ferulic acid decreased nerve tissue pathologies after generated brain trauma compared to injury groups. CONCLUSION: Addition of ferulic acid to the traditional head trauma treatment has the strength, and ability to increase the rate, and percentage of healing (Tab. 2, Fig. 4, Ref. 28). |
||
| Keywords: ferulic acid, head trauma, hippocampus, prefrontal cortex | ||
| Published online: 21-May-2019 | ||
| Year: 2019, Volume: 120, Issue: 5 | Page From: 372, Page To: 379 | |
| doi:10.4149/BLL_2019_061 |
||
|
|
 download file |
|