Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.5, p.380–385, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.120, No.5, p.380–385, 2019

Title: The effects of dexmedetomidine on human internal mammary artery and saphenous vein grafts under hypothermia and normothermia
Author: B. Oc, O. Arun, S. B. Taylan, M. Oc, H. Bariskaner, A. Duman

Abstract: OBJECTIVES: The purpose of this study was to determine the effects of hypothermia and normothermia on the isolated human saphenous vein (SV) and internal mammary artery (IMA) responses to dexmedetomidine.
METHODS: The response of human IMA and SV strips with (E+) and without (E–) endothelium subjected to cumulative concentrations of (10–9, 0–6 M) dexmedetomidine were recorded at 37 °C and at 28 °C. OnE–way ANOVA was used for analysis. A p < 0.05 was considered significant.
RESULTS: At 37˚C dexmedetomidine resulted in similar significant concentration-dependent contractions in both E+ and E– SV strips (p < 0.05). At 37 °C dexmedetomidine resulted in significant concentration-dependent contractions in E+ IMA strips, these contractions were significantly lower at all concentrations of dexmedetomidine in E– compared to E+ IMA strips (p < 0.05). When results between similar groups of SV and IMA strips were compared, the contractions were significantly higher in the IMA strips in E+ and E– at 37 °C and also E– 28 °C groups compared to SV (p < 0.05).
CONCLUSION: In conclusion, dexmedetomidine causes in vitro vasoconstriction in human IMA and SV grafts. These contractions are greater in IMA compared to SV grafts. Endothelium-derived pathways are possibly involved in the contractile responses of IMA. Moderate hypothermia augments vasoconstriction in SV grafts (Fig. 3, Ref. 27).

Keywords: dexmedetomidine, hypothermia, normothermia, in vitro, internal mammary artery, saphenous vein
Published online: 21-May-2019
Year: 2019, Volume: 120, Issue: 5 Page From: 380, Page To: 385
doi:10.4149/BLL_2019_062


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