Home General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.3, p.215–225, 2019

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.38, No.3, p.215–225, 2019

Title: The protective effect of resveratrol against risperidone-induced liver damage through an action on FAS gene expression
Author: S. Azirak, S. Bilgic, D. Tastemir Korkmaz, A. N. Guvenc, N. Kocaman, M. K. Ozer

Abstract: The purpose of the study is to examine the protective effect of resveratrol on the fatty acid synthase gene expression against the side-effects of risperidone in an experimental model in rat liver. In this study, thirty-five female Spraque-Dawley rats were divided into five groups (n = 7): Control, RIS (2 mg/kg risperidone daily), RSV1 (2 mg/kg risperidone + 20 mg/kg resveratrol), RSV2 (2 mg/kg risperidone + 40 mg/kg resveratrol), and RSV3 group (2 mg/kg risperidone + 80  mg/kg resveratrol). On treatment day 15, liver tissue was taken for analysis. The resveratrol treatment significantly reduced weight gain as opposed to the risperidone administration. Moreover, the fatty acid synthase gene expression level increased significantly in RSV1 group (p = 0.011). In addition, resveratrol enhanced the total antioxidant status, high-density lipoprotein cholesterol levels and decreased alanine aminotransferase, aspartate aminotransferase, total cholesterol, gamma glutamyl transpeptidase, low density lipoprotein cholesterol, oxidative stress index, triglycerides, and total oxidant status levels significantly (p

Keywords: Risperidone, Resveratrol, Fatty acid synthase, Liver, Apoptosis
Published online: 06-Jun-2019
Year: 2019, Volume: 38, Issue: 3 Page From: 215, Page To: 225

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