Home General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.3, p.245–251, 2019

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.38, No.3, p.245–251, 2019

Title: Impact of cold adaptation on cardiac tolerance to ischemia/reperfusion. Role of glucocorticoid and thyroid hormones
Author: S. Y. Tsibulnikov, L. N. Maslov, N. V. Naryzhnaya, V. V. Ivanov, Y. V. Bushov, N. S. Voronkov, A. S. Jaggi, Y. Zhang, P. R. Oeltgen

Abstract: We have established that the continuous cold exposure (CCE, 4°C, 4 weeks) causes cold adaptation, increases systolic blood pressure, exerts infarct-limiting effect during coronary artery occlusion (45 min) and reperfusion (2 h). The CCE increases adrenal weight, heart weight and triiodothyronine (T3) level but does not change thymus, spleen weight, serum cortisol, corticosterone and thyroxin (T4) levels. The long-term (4°C, 8 h/day, 4 weeks) intermittent cold exposure (LICE) induces adaptation to the cold and increases T4 level. The brief (4°C, 1.5 h/day, 4 weeks) intermittent cold exposure (BICE) also evokes adaptation to the cold but had no effect on the blood pressure, the cardiac tolerance to ischemia/reperfusion, and does not change thymus, spleen weight, serum cortisol, corticosterone, T3 and T4 levels.

Keywords: Cold adaptation, Heart, Ischemia, Reperfusion
Published online: 06-Jun-2019
Year: 2019, Volume: 38, Issue: 3 Page From: 245, Page To: 251
doi:10.4149/gpb­_2019002
Price: 14.00 €






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