Home FOR AUTHORS General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.3, p.259–264, 2019

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Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.38, No.3, p.259–264, 2019

Title: Age-dependent effect of PPARγ agonist pioglitazone on kidney signaling in borderline hypertensive rats
Author: L. Grešová, M. Kvandová, P. Kvasnička, I. Dovinová

Abstract: The peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor and nutrition factor which takes part in the cellular signaling by several agonists such as pioglitazone. PPARγ can serve as potential target in treatments of metabolic syndrome diseases and/or hypertension. In the present study we investigated the effects of pioglitazone, a PPARγ agonist, on hypertension development in young and adult borderline hypertensive rats (BHR). In renal signaling we observed connections between PPARγ and Nrf2, antioxidant in adult animals and differences between young and adult BHR in Nrf2-activated detoxificant outputs (NQO1, HO-1) and NO-synthases. Blood pressure in animals had been detected by cuff plethysmography, cell signaling in the kidney was studied by gene expression determination using qPCR, and nitric oxide synthase (NOS) activity was measured by radioactive detection. Pioglitazone treatment in adult BHR caused no detectable changes in antioxidant and detoxificant responses. The main effects were observed in blood pressure improvement, endothelial NOS expression and NOS activities in both young and adult BHR.

Keywords: Age-dependence, BHR, Kidney, PPARγ, Nrf2, NOS, Hypertension
Published online: 06-Jun-2019
Year: 2019, Volume: 38, Issue: 3 Page From: 259, Page To: 264

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