Home General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.3, p.265–270, 2019

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.38, No.3, p.265–270, 2019

Title: Lisinopril reverses behavioural alterations in spontaneously hypertensive rats
Author: K. Repova, S. Aziriova, D. Kovacova, S. Trubacova, T. Baka, R. Kanska, A. Barta, P. Stanko, S. Zorad, L. Molcan, M. Adamcova, L. Paulis, F. Simko

Abstract: This study investigated the effect of lisinopril (angiotensin-converting enzyme inhibitor) on potential behavioural alterations in spontaneously hypertensive rats (SHR). Three groups of 15–17-week-old rats were investigated for 2 weeks: Wistar control group, SHR group and SHR+lisinopril group. Systolic blood pressure (SBP) was normal in Wistar rats, SHR expressed hypertension and lisinopril normalized the SBP. We observed increased time spent in and increased frequency of entries to the central area of the open field in SHR, while lisinopril induced a trend to reduce the time spent in the central area of the open field and reduced the frequency of entries there. There was a positive correlation between SBP and reduced anxiety-like behaviour in normotensive rats; no correlations in the SHR or SHR+lisinopril groups were observed. We conclude that lisinopril normalized the increase in SBP and partly reversed the alterations of anxiety-like behaviour in SHR.

Keywords: Lisinopril, Behaviour, Spontaneously hypertensive rats, Hypertension, Anxiety
Published online: 06-Jun-2019
Year: 2019, Volume: 38, Issue: 3 Page From: 265, Page To: 270
doi:10.4149/gpb_2019011


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