Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.38, No.3, p.265–270, 2019 |
||
Title: Lisinopril reverses behavioural alterations in spontaneously hypertensive rats | ||
Author: K. Repova, S. Aziriova, D. Kovacova, S. Trubacova, T. Baka, R. Kanska, A. Barta, P. Stanko, S. Zorad, L. Molcan, M. Adamcova, L. Paulis, F. Simko | ||
Abstract: This study investigated the effect of lisinopril (angiotensin-converting enzyme inhibitor) on potential behavioural alterations in spontaneously hypertensive rats (SHR). Three groups of 15–17-week-old rats were investigated for 2 weeks: Wistar control group, SHR group and SHR+lisinopril group. Systolic blood pressure (SBP) was normal in Wistar rats, SHR expressed hypertension and lisinopril normalized the SBP. We observed increased time spent in and increased frequency of entries to the central area of the open field in SHR, while lisinopril induced a trend to reduce the time spent in the central area of the open field and reduced the frequency of entries there. There was a positive correlation between SBP and reduced anxiety-like behaviour in normotensive rats; no correlations in the SHR or SHR+lisinopril groups were observed. We conclude that lisinopril normalized the increase in SBP and partly reversed the alterations of anxiety-like behaviour in SHR. |
||
Keywords: Lisinopril, Behaviour, Spontaneously hypertensive rats, Hypertension, Anxiety | ||
Published online: 06-Jun-2019 | ||
Year: 2019, Volume: 38, Issue: 3 | Page From: 265, Page To: 270 | |
doi:10.4149/gpb_2019011 |
||
|
download file |
|