Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.6, p.410–416, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.120, No.6, p.410–416, 2019

Title: Sentinel lymph node – historical background and current views on its significance in complex management of breast cancer patients
Author: E. Kubikova, J. Badidova, M. Klein, I. Beder Jr, R. Benus, S. Polak, I. Varga

Abstract: Nowadays, breast cancer is the leading oncological diagnosis in women worldwide. On the other hand, breast cancer treatment can be considered one of the most progressive therapeutic approach in the medical field of oncology. The invasive types of breast cancer have a tendency to spread via lymphatic route, what brings in the issue of sentinel lymph node – the first node into which the lymph drains from a given anatomical location. This review paper discusses the historical background of the concept of sentinel lymph node and focuses on clinical significance of the positivity of sentinel lymph node(s) as well. Modern-day conservative therapeutic surgery of breast cancer should be in accordance with diagnostic and preventive interventions in the axilla, whose rate of invasiveness and morbidity must be also attenuated without worsening the patient´s prognosis and survival rate. Formerly, a complete axillary lymph node dissection was routinely performed for prophylactic and cancer staging purposes. The indiscriminate application of this approach was replaced by sentinel lymph node biopsy. Along with common histopathological examination, immunohistochemistry, as well as modern techniques of molecular biology are often employed. These state-of-the-art methods enabled the identification of micrometastases, or even nanometastases, though their real prognostic value is yet to be concluded (Ref. 52).

Keywords: sentinel node, breast cancer, biopsy, historical background
Published online: 21-Jun-2019
Year: 2019, Volume: 120, Issue: 6 Page From: 410, Page To: 416

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