Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.6, p.456–461, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.120, No.6, p.456–461, 2019

Title: The value of plasma SCUBE1 and oxidative stress parameters in the early diagnosis of acute ovarian torsion
Author: M. Gunaydin, M. Sipahi, T. Kesicioglu, M. Usta, B. Tezcan, V. Y. Tokgoz

Abstract: AIM: The purpose of our study was to determine the diagnostic value of plasma SCUBE1, malondialdehyde (MDA), superoxide dismutase (SOD) and total antioxidant status (TAS) investigated on the 4th hour of ovarian torsion, and at the same time to determine the relation between these markers and histopathological damage occurring in the ovary.
MATERIALS AND METHODS: Sixteen rats were included, eight in the torsion group and eight in the control group. The right ovaries of the rats in the torsion group were rotated clockwise 720 degrees, after which they were fixed and attached to the abdominal wall. The abdominal walls of the control group rats were opened for 1 min and then closed. Relaparotomy was performed 4 h after surgery in both groups, blood specimens were collected for biochemical analyses, and the right ovaries were surgically extracted.
RESULTS: No statistically significant difference was determined in the control and torsion groups’ plasma SCUBE1, SOD and TAS values (p = 0.987, p = 0.33, and p = 0.244, respectively). Torsion group plasma MDA values were significantly higher than those of the control group (p = 0.039). At histopathological evaluation, histological score, apoptotic index and Caspase-3 index values of the torsion group were significantly higher compared to the control group.
CONCLUSION: Plasma SCUBE1 is not useful in the early diagnosis of ovarian torsion. Similarly, use of the oxidative stress markers SOD and TAS does not appear useful in early diagnosis, although MDA may be considered for that purpose (Tab. 2, Fig. 3, Ref. 23).

Keywords: ovarian torsion, SCUBE1, oxidative stress
Published online: 21-Jun-2019
Year: 2019, Volume: 120, Issue: 6 Page From: 456, Page To: 461

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