Home Neoplasma 2020 Neoplasma Vol.67, No.1, p.171–177, 2020

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.67, No.1, p.171–177, 2020

Title: Circular RNA circHIPK3 serves as a prognostic marker to promote chronic myeloid leukemia progression
Author: X. Q. Feng, S. M. Nie, J. X. Huang, T. L. Li, J. J. Zhou, W. Wang, L. K. Zhuang, F. J. Meng

Abstract: Increasing evidence demonstrate that circular RNAs (circRNAs) play critical role in regulation of gene expression, which participate in the pathogenesis of cancer, including chronic myeloid leukemia (CML). In this study, we aimed to investigate the expression profiling of circHIPK3 in CML. We found that circHIPK3 was significantly upregulated in peripheral blood mononuclear cells (PBMC) and serum samples from CML compared with healthy controls. High circHIPK3 expression predicted a poor outcome of CML patients. Further loss-function experiments suggested the oncogenic role of circHIPK3 in CML. Our findings provide insights on the role of circHIPK3 in the development and treatment of CML.

Keywords: chronic myeloid leukemia, circRNAs, outcome, miR-124
Published online: 29-Jan-2020
Year: 2020, Volume: 67, Issue: 1 Page From: 171, Page To: 177

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