Home Neoplasma 2019 Neoplasma Vol.66, No.6, p.879–886, 2019

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.66, No.6, p.879–886, 2019

Title: miRNA and mRNA expression profiles in gastric cancer patients and the relationship with circRNA
Author: F. Jiang, X. B. Shen

Abstract: Gastric cancer (GC) is a malignant tumor that affects individuals worldwide, and miRNA and mRNA are closely connected to this disease. However, it is still unclear how these molecules affect GC and whether their effects are associated with circRNA in GC patients. Therefore, we obtained the miRNA, mRNA and circRNA expression profiles of GC patients from the GEO database. For comparison, shared miRNAs and mRNAs from the results of microarrays were annotated by gene ontology (GO) and pathway analysis. We also identified mRNAs that were targeted by miRNA through TargetScan 7.2 and circRNAs that were targeted by miRNA through CircInteractome. A comprehensive analysis of the microarray results revealed 72 shared miRNAs, and the expression profiles of 6 miRNAs were significantly different between the tumor and control groups (the absolute value of fold change >2, p2, p). In conclusion, the circ0001658/circ0004928/circ0000376-miR-375-PAX6 axis may represent a new regulatory network that should be further investigated, and the results of this study provide a better understanding of GC.

Keywords: gastric cancer, miRNAs, mRNAs, circRNAs, GEO
Published online: 09-Jul-2019
Year: 2019, Volume: 66, Issue: 6 Page From: 879, Page To: 886

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