Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.7, p.527–531, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.120, No.7, p.527–531, 2019

Title: Melatonin treatment prevents carbon tetrachloride-induced acute lung injury in rats by mitigating tissue antioxidant capacity and inflammatory response
Author: M. Radovic, L. Ristic, D. Krtinic, M. Rancic, V. Nickovic, ZN. Vujnovic Zivkovic, JB Zivkovic, MV Mirkovic, DR. Toskic, D. Sokolovic

Abstract: AIM: Carbon tetrachloride (CCl4) is an organic chemical that produces different tissue‑damaging effects when ingested or inhaled. Present study aims to determine whether the application of exogenous melatonin, a neurohormone with numerous biological properties, can prevent disturbances in lung tissue antioxidative capacities and arginine metabolism, tissue inflammation and oxidative damage induced by exposure to CCl4 in rats.
METHODS: The effects of melatonin on the changes occurring in rat lung tissue after an acute exposure to CCl4 were studied by monitoring alterations in antioxidant capacities, inflammatory parameters, parameters of arginine metabolism, and lipid and protein oxidative damage.
RESULTS: The results indicated that melatonin prevents CCl4-induced lung damage by mitigating tissue antioxidant capacity and preventing nitric oxide production through a shift from nitric oxide synthase to arginase. Also, melatonin partially prevented tissue inflammation and molecules’ oxidative modification seen after exposure to CCl4.
CONCLUSIONS: The protective activity of melatonin can be attributed to its ability to scavenge both free radicals, as well as to its potential to increase tissue antioxidant capacity. The modulation of inflammatory response through both decrease in tissue inflammatory parameters and influence on arginine-nitric oxide metabolism might be an additional mechanism of action (Tab. 1, Fig. 2, Ref. 33).

Keywords: lung injury, carbon tetrachloride, melatonin, tissue antioxidant capacity, arginine metabolism
Published online: 12-Jul-2019
Year: 2019, Volume: 120, Issue: 7 Page From: 527, Page To: 531
doi:10.4149/BLL_2019_085


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