Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.7, p.532–535, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.120, No.7, p.532–535, 2019

Title: Urinary megalin in association with progression factors of diabetic nephropathy
Author: A. Akour, V. Kasabri, N. Bulatova, Y. Al-Motassem, H. Fahmawi, M. Momani, A. Zayed, R. Alquoqa, H. AlHawari

Abstract: AIM: The aim of this study is to evaluate the association between urinary megalin, renal function, blood pressure, lipid profile, vitamin D and glycemic control in patients with type 2 diabetes mellitus (T2DM).
METHODS:. This was a cross-sectional study which recruited 209 patients with T2DM. Urinary megalin was positively associated with systolic blood pressure (SBP) (r=0.218, p=0.04) but negatively with glomerular filtration rate (GFR) (r=–0.16, p=0.023). The levels of urinary albumin, triglycerides (TGs) and glycosylated hemoglobin (HbA1c) were higher in the “high-megalin” group, compared to those in “low-megalin” group. Moreover, there was a significant inverse association between vitamin D3 levels and megalin levels in urine (OR=0.281, p=0.047).
CONCLUSION: Our study showed for the first time that megalin is associated with progression factors of diabetic nephropathy as well as vitamin D deficiency (Tab. 3, Fig. 1, Ref. 15).

Keywords: diabetic nephropathy, progression factors, biomarker, type 2 diabetes, megalin
Published online: 12-Jul-2019
Year: 2019, Volume: 120, Issue: 7 Page From: 532, Page To: 535
doi:10.4149/BLL_2019_086


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