Home HOME Neoplasma 2019 Neoplasma Vol.66, No.5, p.792–800, 2019

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.66, No.5, p.792–800, 2019

Title: NKAP plays an oncogenic function partly through AKT signaling pathway in hepatocellular carcinoma
Author: T. Song, J. Y. Liu, J. J. Yang

Abstract: NF-κB activating protein (NKAP) is a highly conserved protein involved in transcriptional repression, immune cell development, maturation, T cell acquisition of functional competency and maintenance of hematopoiesis. Here, we first explore the function of NKAP in hepatocellular carcinoma (HCC). We found that NKAP was highly expressed in HCC tissues and associated with a poor patient survival. CCK8 assay showed that NKAP knockdown significantly decreased cell viability of HuH7 and Hep3B HCC cell lines. Cell invasion, tested by transwell assays, was significantly inhibited by NKAP knockdown in HuH7 and Hep3B cells (pknockdown also played an oncogenic role in human gastric cancer AGS and MKN45 cells. In conclusion, our study for the first time reveals that NKAP promotes the proliferation and invasion in HCC cell lines at least partly through AKT signaling pathway.

Keywords: NKAP, HCC, apoptosis, AKT
Published online: 30-Sep-2019
Year: 2019, Volume: 66, Issue: 5 Page From: 792, Page To: 800

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