Home Neoplasma 2019 Neoplasma Vol.66, No.6, p.995–1001, 2019

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.66, No.6, p.995–1001, 2019

Title: Prognostic significance of preoperative radiotherapy in stage II and III rectal cancer patients: A Strobe-compliant study of SEER 18 registries database (1988–2011)
Author: R. WANG, D. ZHAO, Y. J. LIU, C. YE, J. R. QIAN, J. N. DAI, S. Y. LIU, J. Y. LIU, B. LI, M. J. WANG, J. PING

Abstract: Preoperative radiation therapy has been regarded as the optional neoadjuvant treatment to decrease local recurrence of rectal cancer in addition to surgery. However, its benefit in survival remained obscure. This study was aimed to measure the efficacy of preoperative radiation therapy for survival in stage II and III rectal cancer patients. Retrospective cohort study used the database of Surveillance, Epidemiology and End Results program of the National Cancer Institute in the United States from 1988 to 2011. A total of 49,439 patients diagnosed with primary rectal cancer who underwent surgery were included. Clinicopathological characteristics and rectal cancer-specific survival between surgery alone group and surgery plus preoperative radiation therapy group were compared. Rectal cancer patients in surgery plus preoperative radiation therapy group had significantly better survival than those in surgery alone group (72.70% vs. 66.61%, p

Keywords: preoperative radiotherapy, rectal cancer, survival, Surveillance, Epidemiology and End Results database
Published online: 15-Jul-2019
Year: 2019, Volume: 66, Issue: 6 Page From: 995, Page To: 1001
doi:10.4149/neo_2019_190112N36
Price: 14.70 €






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