Home Neoplasma 2019 Neoplasma Vol.66, No.6, p.1002–1008, 2019

Journal info


6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.66, No.6, p.1002–1008, 2019

Title: Association between CA repeat polymorphism in IGF1 gene promoter and colorectal cancer risk in a native Chinese population
Author: X. L. CHAO, L. L. WANG, R. LIU, Y. LI, X. J. ZHOU

Abstract: Insulin-like growth factor 1 (IGF1) is implicated in normal cell growth. It has been reported that IGF1 has a mitogenic and anti-apoptotic effect on colorectal cancer cells. However, results of studies on the association between cytosine-adenine (CA) repeat polymorphism in IGF1 gene promoter and colorectal cancer (CRC) risk are inconsistent. We aimed to evaluate the association between CA repeat polymorphism and CRC risk, as well as the relationship with the clinicopathological characteristics of CRC and circulating IGF1 level in a native Chinese population. There were 734 participants who were native Chinese in this case-control study, including 367 CRC cases and 367 age- and sex-matched controls. CA repeat polymorphism was genotyped by PCR and fragment analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were evaluated by unconditional logistic regression analysis. Circulating level of IGF1 in cases was significantly higher than that in controls (p=0.002), particularly in males. Less than 38 CA repeats were associated with decreased CRC risk after adjusting for age and sex (37 versus 38 CA repeats: OR=0.45; 95% CI=0.26–0.78), especially in males. (CA)18/19 genotype showed approximately half reduced CRC risk comparing to (CA)19/19 genotype (OR=0.46; 95% CI=0.25–0.85). There was a significant association between the sum of CA repeats and degree of differentiation of CRC (p=0.044). We observed a trend that circulating level of IGF1 in individuals with CA ≤38 repeats was lower than that in individuals with CA >38 repeats with a borderline statistical significance in overall and males. In conclusion, our findings support the possible role of CA repeat polymorphism in CRC risk.

Keywords: insulin-like growth factor 1, polymorphism, CA repeat, colorectal cancer
Published online: 15-Jul-2019
Year: 2019, Volume: 66, Issue: 6 Page From: 1002, Page To: 1008
doi:10.4149/neo_2019_190117N51
Price: 14.70 €






© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.