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General Physiology and Biophysics Vol.38, No.4, p.365–368, 2019 |
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Title: Post-weaning social isolation of rats induces reduction in the gene expression of vascular endothelial growth factor (VEGF) in the hippocampus | ||
Author: Magdalena Chmelova, Daniela Jezova, Igor Riecansky, Natasa Hlavacova | ||
Abstract: The role of vascular endothelial growth factor (VEGF) in chronic stress and neurodevelopmental disorders is of growing research interest. Here we show that post-weaning isolation rearing of rats decreased gene expression of VEGF in the hippocampus. Gene expression of VEGF upstream regulator fibroblast growth factor-2 (FGF-2) or its downstream mediator endothelial nitric oxide synthase (eNOS) was unchanged. Other signaling pathways appear to be involved in isolation-induced reduction in VEGF gene expression. Sex differences in VEGF and eNOS gene expression with significantly higher mRNA levels in females than males were revealed. |
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Keywords: Isolation — Sex differences — Growth factors — Gene expression — Hippocampus | ||
Published online: 15-Jul-2019 | ||
Year: 2019, Volume: 38, Issue: 4 | Page From: 365, Page To: 368 | |
doi:10.4149/gpb_2019019 |
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