Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.8, p.566–568, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.120, No.8, p.566–568, 2019

Title: Analysis of hemocoagulation tests for prediction of venom-induced consumption coagulopathy development after Viperidae bite
Author: J. Valenta, Z. Stach, M. Porizka, P. Michalek

Abstract: OBJECTIVE: Viperidae snakes are responsible for 95 % of the bites caused by exotic-bred snakes in our country. Their envenoming may be associated with a severe acute coagulation disorder – venom-induced consumption coagulopathy (VICC). Thus, its early prediction is vital for an adequate therapy including antivenom delivery.
MATERIAL AND METHODS: Laboratory coagulation tests of 14 patients suffering from VICC were processed and statistically analyzed to evaluate the importance of individual parameters in the time after the bite.
RESULTS: The pathological values of D-dimer (D-dim) and fibrinogen (FBG) were found to be the first indicators of VICC development, with a median time of 4.55 hours since the bite, while median values for prothrombin time and international normalized ratio (PT/INR), activated partial thromboplastin time (APTT), and thrombin time (TT) were 5.9 h, 8.15 h, and 5.5 h, respectively. In the first samples, the values of D-dim were found to be pathologically increased in all 14 patients, while pathological levels of FBG were seen only in 11 cases. PT/INR and APTT were prolonged in 8 and 6 cases, respectively.
CONCLUSION: An increase in D-dim values was found to be the first parameter signaling developing VICC in all analyzed cases (Tab. 2, Ref. 12).

Keywords: snakebite, Viperidae, envenoming, hemocoagulation, venom-induced consumption coagulopathy
Published online: 29-Jul-2019
Year: 2019, Volume: 120, Issue: 8 Page From: 566, Page To: 568
doi:10.4149/BLL_2019_092


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