Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.8, p.576–580, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.120, No.8, p.576–580, 2019

Title: Effects of cinchonine, a Cinchona bark alkaloid, on spontaneous and induced rat ileum contractions
Author: G. Rankovic, V. Stankovic, M. Zivkovic, B. Rankovic, D. Laketic, M. Potic, M. Saranovic, G. Nedin Rankovic

Abstract: AIM: Quinine, a frequently used anti-malaria alkaloid isolated from the Cinchona bark, possesses numerous toxic properties, the majority of which arrive from a dysfunction of the gastrointestinal tract. Similarly, cinchonine, another alkaloid from the Cinchona bark, displays a great potential for treating malaria (especially the resistant forms).
METHODS: In this work, we aimed to evaluate the effects of cinchonine on spontaneous and induced Wistar rat ileum contractions in order to uncover potential side effects that might arise after its application.
RESULTS: Cinchonine produced a concentration-dependent spasmolytic activity, which was found to be reversible (i.e. disappeared after tissue wash-up), with an IC50 value of 273 µM. Furthermore, the mechanism of action of cinchonine at IC50 elucidated through experiments with acetylcholine and Ca2+-induced ileum contractions. The applied IC50 concentration of cinchonine statistically significantly prevented the occurrence of contractions after the application of specific agonist. The obtained results are in a range with the effects seen with standard receptor antagonists, i.e. atropine and verapamil.
CONCLUSIONS: The obtained results showed that cinchonine inhibited both types of induced contractions, suggesting a Ca2+-channels mediated modus operandi (Fig. 4, Ref. 19).

Keywords: cinchonine, Cinchona bark, ileum, spasmolytic, calcium channels
Published online: 29-Jul-2019
Year: 2019, Volume: 120, Issue: 8 Page From: 576, Page To: 580
doi:10.4149/BLL_2019_094


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