Home 
Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.8, p.576–580, 2019
Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.8, p.576–580, 2019
Journal info
|
||||
Select Journal
Journals
Bratislava Medical Journal 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Bratislava Medical Journal Vol.120, No.8, p.576–580, 2019 |
||
| Title: Effects of cinchonine, a Cinchona bark alkaloid, on spontaneous and induced rat ileum contractions | ||
| Author: G. Rankovic, V. Stankovic, M. Zivkovic, B. Rankovic, D. Laketic, M. Potic, M. Saranovic, G. Nedin Rankovic | ||
| Abstract: AIM: Quinine, a frequently used anti-malaria alkaloid isolated from the Cinchona bark, possesses numerous toxic properties, the majority of which arrive from a dysfunction of the gastrointestinal tract. Similarly, cinchonine, another alkaloid from the Cinchona bark, displays a great potential for treating malaria (especially the resistant forms). METHODS: In this work, we aimed to evaluate the effects of cinchonine on spontaneous and induced Wistar rat ileum contractions in order to uncover potential side effects that might arise after its application. RESULTS: Cinchonine produced a concentration-dependent spasmolytic activity, which was found to be reversible (i.e. disappeared after tissue wash-up), with an IC50 value of 273 µM. Furthermore, the mechanism of action of cinchonine at IC50 elucidated through experiments with acetylcholine and Ca2+-induced ileum contractions. The applied IC50 concentration of cinchonine statistically significantly prevented the occurrence of contractions after the application of specific agonist. The obtained results are in a range with the effects seen with standard receptor antagonists, i.e. atropine and verapamil. CONCLUSIONS: The obtained results showed that cinchonine inhibited both types of induced contractions, suggesting a Ca2+-channels mediated modus operandi (Fig. 4, Ref. 19). |
||
| Keywords: cinchonine, Cinchona bark, ileum, spasmolytic, calcium channels | ||
| Published online: 29-Jul-2019 | ||
| Year: 2019, Volume: 120, Issue: 8 | Page From: 576, Page To: 580 | |
| doi:10.4149/BLL_2019_094 |
||
|
|
 download file |
|