Home Acta Virologica 2019 Acta Virologica Vol.63, No.3, p.286-291, 2019

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

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Acta Virologica Vol.63, No.3, p.286-291, 2019

Title: Schmallenberg virus affects T-bet, Gata3, RoRrγt, Foxp3 and Eomes in mice brain
Author: E. AKSOY, A. K. AZKUR

Abstract: Schmallenberg virus (SBV), a neurotropic member of the genus Orthobunyavirus, infects ruminants and causes neurological lesions and fetal malformations including cerebellar hypoplasia, hydranencephaly, and porencephaly. The aim of this study is to establish intracerebral (i.c.) infection of SBV in newborn BALB/c mice and to investigate some of the transcription factors in brain. For this aim, brain samples of newborn BALB/c mice which were infected with SBV i.c. were analyzed by plaque titration and real-time RT-PCR for T-bet, Gata3, RoRγt, Foxp3 and Eomes mRNA levels. Study results showed that SBV can replicate in BALB/c mice brain and cause death of newborn mice with generation of infectious viral particles. Analyses of transcription factor mRNA levels indicated up-regulation of T-bet, Gata3, RoRγt, Foxp3 and down-regulation of Eomes. In this report, we introduce preliminary data of T cell transcription factors affected by SBV infection of BALB/c mice.

Keywords: Eomes; Foxp3; Gata3; RoRγt; Schmallenberg virus; T-bet
Published online: 09-Sep-2019
Year: 2019, Volume: 63, Issue: 3 Page From: 286, Page To: 291
doi:10.4149/av_2019_306


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