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HOME Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.9, p.668-672, 2019
HOME Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.9, p.668-672, 2019
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Bratislava Medical Journal Vol.120, No.9, p.668-672, 2019 |
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| Title: The use of granulocyte colony stimulating factor after autologous hematopoietic stem cell transplantation | ||
| Author: F. Farkas, M. Mistrik, A. Batorova | ||
| Abstract: Restrospective study to evaluate the efficacy of early vs. delayed initiation of G-CSF after autologous hematopoietic stem cell transplantation (AHSCT) in patients with lymphoid malignancies. BACKGROUND: Granulocyte colony stimulating factor (G-CSF) is commonly used after AHSCT to accelerate stem cell engraftment to minimize the morbidity and mortality associated with prolonged neutropenia. However, there is no consensus on the optimal timing of G-CSF after HSCT. METHODS: A total of 117 patients with lymphoid malignancies who underwent AHSCT were included. All patients received G-CSF (filgrastim 5 μg/kg s.c.) daily after AHSCT (43 patients on day 6–8 and 74 patients on day 3 or 4). All patients received standard conditioning regimen for the underlying disease, and standard supportive treatment, including treatment of febrile neutropenia. RESULTS: The incidence of severe neutropenia was 81 % vs 17 %, and very severe neutropenia 61 % vs 4 % in the delayed and early G-CSF groups, respectively (p < 0.0001). The rate of fungal infection was higher in the group of patients who received delayed G-CSF (p < 0.005). CONCLUSION: An early administration of G-CSF after AHSCT (on day 3 or 4) accelerates neutophil engraftment; decreases the incidence of severe neutropenia and the risk of infectious complications (especially fungal infections) (Tab. 1, Fig. 3, Ref. 22). |
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| Keywords: autologous HSCT, G-CSF, lymphoid malignancies, engraftment, febrile neutropenia | ||
| Published online: 28-Aug-2019 | ||
| Year: 2019, Volume: 120, Issue: 9 | Page From: 668, Page To: 672 | |
| doi:10.4149/BLL_2019_111 |
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