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General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.5, p.399–406, 2019
General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.5, p.399–406, 2019
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General Physiology and Biophysics Vol.38, No.5, p.399–406, 2019 |
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| Title: Modulation of inhibitory and excitatory neurotransmissions by Zn2+ on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice | ||
| Author: Hoang T. T. Nguyen, Seon Hui Jang, Soo Joung Park, Dong Hyu Cho, Seong Kyu Han | ||
| Abstract: The substantia gelatinosa of the trigeminal subnucleus caudalis has been considered to be an essential location for the transference of orofacial sensory signals. The co-localization of inhibitory and excitatory neurotransmitters in the same substantia gelatinosa (SG) neurons has demonstrated their essential part in the modification of nociceptive transmission. Zn2+ is particularly numerous in the mammalian central nervous system. There are proofs demonstrating the role of Zn2+ in the modulation of voltage- and ligand-gated ion channels. However, little is known about what roles Zn2+ may play in the modulation of signal transmission in the SG neurons of the trigeminal subnucleus caudalis (Vc). Therefore, in this study, we used the whole-cell patch clamp technique to find out the effect of Zn2+ on the responses of three main neurotransmitters (glycine, GABA, and glutamate) on SG neurons of the Vc in mice. We have proved that Zn2+ induces a big potentiation of glycine receptor-mediated response but attenuates GABA- and glutamate-induced responses at micromolar concentrations, however, enhances glutamate-induced response at nanomolar concentration. Taken together, these data demonstrated that Zn2+ can modulate glycine, GABA and glutamate-mediated actions on the SG neurons of the Vc and support an important mechanism in spinal sensory information signaling. |
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| Keywords: Substantia gelatinosa, Patch clamp techniques, Zn2+ | ||
| Published online: 30-Sep-2019 | ||
| Year: 2019, Volume: 38, Issue: 5 | Page From: 399, Page To: 406 | |
| doi:10.4149/gpb_2019027 |
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