Home General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.5, p.407–416, 2019

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.38, No.5, p.407–416, 2019

Title: Involvement of P2X7 receptors in satellite glial cells of dorsal root ganglia in the BmK I -induced pain model of rats
Author: Jingjing Zhou, Danting Feng, Xiaoxue Zhang, Chenchen Xia, Zhiping Zhang, Jiahao Kang, Zhiyong Tan, Bin Wu
Abstract: The P2X7 receptor (P2X7R) plays an important role in inflammatory and neuropathic pain. Our recent study indicated that activation of P2X7R in microglial cells of spinal cord contributes to the inflammatory pain induced by BmK I, the major active compound from Buthus martensi Karsch (BmK). In the present study, we further investigated whether P2X7R in satellite glial cells (SGCs) of dorsal root ganglion (DRG) is involved in the BmK I-induced pain in rats. The results found that the expression of P2X7R in SGCs was increased in the ipsilateral side of L4–L5 DRGs after intraplantar injection of BmK I. Moreover, the expression of an inflammatory cytokine IL-1β was increased in DRG after BmK I injection. Systemic administration of an inhibitor of P2X7R (A-438079) significantly inhibited both spontaneous and evoked nociceptive behaviors induced by BmK I. These results suggest that the P2X7R in SGCs of DRG might contribute to pain induced by toxins that sensitize peripheral sensory nerves.
Keywords: Pain, Dorsal root ganglia, Interleukin 1 beta, Satellite glial cell, P2X7 receptor, BmK I
Published online: 30-Sep-2019
Year: 2019, Volume: 38, Issue: 5 Page From: 407, Page To: 416
doi:10.4149/gpb_2019026


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