Home Neoplasma 2019 Neoplasma Vol.66, No.6, p.954–962, 2019

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.66, No.6, p.954–962, 2019

Title: A MYC target long non-coding RNA GATA2-AS1 regulates non-small cell lung cancer growth
Author: L. Zhang, L. Gao, M. Shao, G. Y. Sun

Abstract: Non-small cell lung cancer (NSCLC) is the most prevalent subtype of lung cancer histologically, and an increasing number of evidences have shown during the past years that long non-coding RNAs (lncRNAs) are involved in tumorigenesis. Here we found a long non-coding RNA, GATA2-AS1, repressing NSCLC cells proliferation via regulating GATA2. GATA2-AS1 gene is located at antisense strand of GATA2 on chromosome while GATA2-AS1 RNA interacts with GATA1 protein at promoter region of GATA2 and then inhibits its transcription. Moreover, GATA2-AS1 is transcriptionally repressed by MYC in NSCLC cells. To conclude, our study discovered the role of lncRNA GATA2-AS1 in human non-small cell lung cancer growth thus providing a potential target for lung cancer drugs.

Keywords: NSCLC, lncRNA, MYC, GATA2
Published online: 13-Oct-2019
Year: 2019, Volume: 66, Issue: 6 Page From: 954, Page To: 962
doi:10.4149/neo_2019_190210N112
Price: 18.90 €






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