Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.10, p.777-782, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.120, No.10, p.777-782, 2019

Title: Effects of trimetazidine on nerve regeneration in a rat sciatic nerve injury model
Author: G. Karahan, H. Kaya, M. A. Erdogan, G. Yigitturk, E. Gokyayla, O. Erbas

Abstract: AIM: The aim of this study was to evaluate the efficacy of trimetazidine(TMZ) after end-to-end repair in a peripheral nerve injury model.
METHOD: We performed end-to-end primary repair of sciatic nerves in rats and showed TMZ’s regenerative effect. For this objective 30 male Sprague Dawley albino rats were used. Surgery+water group, rats were assigned to a placebo group and were given water by oral gavage. Surgery+TMZ group, rats were given trimetazidine by oral gavage. All medications were given for 12 weeks. Motor function test was performed. Afterwards, electromyography (EMG) recording was done. Finally, blood samples were taken, the animals were euthanized andsciatic nerve was removed.
RESULTS: The amplitudes of compound muscle action potential (CMAP) increased significantly in the Surgery+TMZ group when compared with the group that have been given Surgery+Water. Nerve growth factor (NGF) immunoexpression in the Schwann cell was significantly increased in the Surgery+TMZ group compared with the Surgery+Water group. Moreover, fibrosis score was reduced in the Surgery+TMZ group compared to the Surgery+Water group.
CONCLUSİONS: In conclusion, we demonstrated the superiority of TMZ on nerve healing in our experimental study which was evaluated with comparative groups (Tab. 3, Fig. 2, Ref. 31).

Keywords: trimetazidine, nerve injury, primary repair, nerve regeneration
Published online: 28-Oct-2019
Year: 2019, Volume: 120, Issue: 10 Page From: 777, Page To: 782
doi:10.4149/BLL_2019_130


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