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FOR AUTHORS Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.10, p.789-793, 2019
FOR AUTHORS Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.10, p.789-793, 2019
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Bratislava Medical Journal Vol.120, No.10, p.789-793, 2019 |
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| Title: Effect of intralipid administration on calcium therapy in verapamil toxicity | ||
| Author: S. Baltaci Ozen, S. H. Celebi, D. Coskun, I. Gungor, G. Inan | ||
| Abstract: Aim: Lipid emulsions are promising with regard to the treatment of toxicity by agents of high lipophilic nature. Our objective is to investigate the efficacy of intralipid 20% and calcium administration at different times when symptoms of cardiac toxicity occur during verapamil infusion. Method: 24 adult male Spraque-Dawley rats were randomly divided into 4 different groups, the control group, calcium group, calcium following 20% intralipid group and concomitant 20% intralipid and calcium group. Following monitoring under ketamine anesthesia, all groups were administered 37.5 mg kg-1 h-1 verapamil infusion until a 50% decrease occurred in MAPb. At the end of the infusion, verapamil infusion was decreased down to 15 mg kg-1h-1 and the treatment agents predetermined for the groups were administered concomitantly. Results: There is no statistically significant difference between the administration of 20% intralipid synchronized with calcium or as a pretreatment, but both groups provided a higher survival rate when compared to the other groups. Conclusions:The administration of calcium alone in verapamil toxicity is not sufficient; when calcium and 20% intralipid are administered together, there is no difference between the administration of lipid and calcium concomitantly and the administration of lipid prior to calcium (Tab. 1, Fig. 2, Ref. 23). |
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| Keywords: Verapamil, toxicity, intravenous lipid emulsion, calcium | ||
| Published online: 28-Oct-2019 | ||
| Year: 2019, Volume: 120, Issue: 10 | Page From: 789, Page To: 793 | |
| doi:10.4149/BLL_2019_132 |
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