Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.11, p.813–818, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.120, No.11, p.813–818, 2019

Title: Preventative effect of diclofenac sodium and/or diltiazem in rats with epidural fibrosis
Author: B. Erdogan, M. Is, F. V. Aker, S. T. Emon, T. Engin, E. A. Akar, E. Sayman, H. Somay

Abstract: OBJECTIVE: Spinal epidural fibrosis is commonly seen after laminectomy. There is not yet proven any agent preventing fibrosis in clinical usage. We used diclofenac sodium and diltiazem, which are fibrosis inhibitors.
METHODS AND MATERIALS: 40 rats were divided into four groups of equal numbers: control, diclofenac sodium, diltiazem, and diclofenac sodium + diltiazem. Laminectomies were performed at L5 and L6. After a 4 week period, the rats were decapitated and the vertebral column blocks were removed for histopathologic examination. Fibrosis percentage, spread of fibrous regions, and fibroblast numbers were evaluated in each group and compared between the groups.
RESULTS: The distribution of epidural fibrosis density, percentage of fibrosis, and distribution of fibroblasts in the diclofenac sodium + diltiazem group were significantly lower than in the other groups. The fibroblast numbers of the diltiazem, and diclofenac sodium + diltiazem groups were significantly lower than in the other groups.
CONCLUSION: Diclofenac sodium + diltiazem used together provided better outcomes because each of them prevented fibrosis via different ways, probably through synergistic action (Tab. 5, Fig. 3, Ref. 43).

Keywords: diltiazem, diclofenac sodium, epidural fibrosis, laminectomy
Published online: 20-Nov-2019
Year: 2019, Volume: 120, Issue: 11 Page From: 813, Page To: 818
doi:10.4149/BLL_2019_135


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