Home General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.6, p.519–524, 2019

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
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General Physiology and Biophysics Vol.38, No.6, p.519–524, 2019

Title: The effect of resveratrol on oxidative ovary-damage induced by methotrexate in rats (Resveratrol oxidative ovary-damage)
Author: Nahit Ata, Nur G. Kulhan, Mehmet Kulhan, Can Turkler, Tunay Kiremitli, Sevil Kiremitli, Ferda Keskin Cimen, Halis Suleyman, Veysel Toprak
Abstract: Methotrexate (MTX) is a commonly used folic acid antagonist for the treatment of neoplasia and some autoimmune diseases. Resveratrol has important anti-inflammatory, antioxidant and immunomodulatory properties. The aim of this study was to investigate the effects of resveratrol on MTX-induced ovary-damage and oxidative stress in rats. We hypothesized that supplement of resveratrol could counteract MTX-induced cytotoxicity in rat ovary. Albino Wistar female rats were randomly divided into three groups: Healthy control (HC), resveratrol + methotrexate (RMTX) and methotrexate (MTX) group. Their ovaries were removed. Biochemical and histopathological methods were utilized for evaluation of the oxidative ovary-damage. MDA was found to be higher but tGSH and SOD were lower in the ovarian tissue of the rat group administered MTX, but it is observed that these ratios are reversed in HC and in RMTX groups. MTX treatment induced ovary damage and especially pre-treatment with resveratrol provided protective effect against this MTX-induced ovary-damaged.
Keywords: Methotrexate, Oxidative ovary-damage, Resveratrol
Published online: 27-Nov-2019
Year: 2019, Volume: 38, Issue: 6 Page From: 519, Page To: 524
doi:10.4149/gpb_20190281


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