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General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.6, p.535–544, 2019
General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.6, p.535–544, 2019
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General Physiology and Biophysics Vol.38, No.6, p.535–544, 2019 |
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| Title: Effects of subchronic methionine stimulation on oxidative status and morphological changes in the rat ileum | ||
| Author: Dušan Todorović, Marija Stojanović, Ljiljana Šćepanović, Dušan Mitrović, Vuk Šćepanović, Radomir Šćepanović, Teja Šćepanović, Milica Labudović-Borović, Vesna Dragutinović, Nevena Borozan, Dragan Djuric | ||
| Abstract: This study was conducted to explore the effects of sulfur containing amino acids on redox status and morphological parameters in the rat ileum tissue. Male Wistar albino rats were randomly divided into the following groups: K group (saline, 1 ml/day, i.p.), M group (methionine, 0.8 mmol/kg/day, i.p.), C group (methionine (0.8 mmol/kg/day) + L-cysteine (7 mg/kg/day), i.p.) and N group (methionine (0.8 mmol/kg/day) + N-acetyl-L-cysteine (50 mg/kg/day), i.p.). Activities of antioxidant enzymes in the ileum were analyzed to profile oxidative status. Morphometric analysis included measurement of villus height (μm), tunica mucosa thickness (μm), tunica muscularis thickness (μm), the total thickness of the ileal wall (μm) and the number of cells in the lamina propria (per 0.1 mm2 of tissue). Results showed that methionine treatment reduced the activity of antioxidant enzymes (SOD, GPx, CAT) and the GSH content compared to the control group (p > 0.05). The application of methionine reduced the following parameters statistically significant compared to the control group: length of the ileal villi (p |
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| Keywords: Rat, Ileum, Methionine, Oxidative status | ||
| Published online: 27-Nov-2019 | ||
| Year: 2019, Volume: 38, Issue: 6 | Page From: 535, Page To: 544 | |
| doi:10.4149/gpb_2019033 |
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