Home General Physiology and Biophysics 2019 General Physiology and Biophysics Vol.38, No.6, p.545–556, 2019

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
6 times per year

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General Physiology and Biophysics Vol.38, No.6, p.545–556, 2019

Title: Effects of nicorandil on vascular and renal dysfunctions in adenine-induced nephropathy: Possible underlying mechanisms
Author: Abdelaziz M. Hussein, Mohamed Eldosoky, Hala Abdel Malek, Mohamed Elshafey, Eman El Nashar, Gamal Dahab
Abstract: Vascular dysfunctions in chronic kidney disease (CKD) include endothelial dysfunctions and vascular calcification (VC). In the present study, we examined the possible protective effect of nicorandil (potassium channel opener) on renal and vascular dysfunctions in a rat model of adenine-induced nephropathy and its underlying mechanisms. Thirty-four male Sprague-Dawley rats were randomly allocated into 3 groups: Control group, Adenine group (animals received high-adenine diet for 4 weeks), and Nicorandil group (animals received adenine for 4 weeks and nicorandil 1 mg/kg per oral for 4 weeks). The results showed significant reduction in the body weight, heart rate (HR), hemoglobin contents, serum Ca2+ and reduction in the expression of mRNA of endothelial nitric oxide synthase (eNOS) and nuclear factor erythroid related factor 2 (nrf2) genes in aortic tissues with significant increase in arterial blood pressure (ABP), serum creatinine, blood urea nitrogen (BUN), plasma renin activity (PRA), K+ and phosphate (PO43-), urinary albumin excretion (UAE) and aortic VC in Adenine group compared to normal group (p
Keywords: Nicorandil, Adenine, Vascular calcifications, Kidney, eNOS, Nrf2
Published online: 27-Nov-2019
Year: 2019, Volume: 38, Issue: 6 Page From: 545, Page To: 566
doi:10.4149/gpb_2019034


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