Home HOME Neoplasma 2020 Neoplasma Vol.67, No.1, p.119–128, 2020

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.67, No.1, p.119–128, 2020

Title: Decreased expression of SorCS1 in colorectal cancer: An independent predictor of poor prognosis
Author: P. Z. Huang, S. Y. Peng, H. C. Yu, L. Huang, Q. Yao, X. L. Wang, S. Y. Tan, J. M. Zhou, P. N. Wang, A. P. Huang, L. L. Bai, Y. X. Luo, M. J. Huang

Abstract: Previously, we identified that sortilin related VPS10 domain containing receptor 1 (SorCS1) was hypermethylated in colorectal cancer (CRC) tissues. Here, we aimed to investigate the association between CRC and SorCS1. DNA methylation was determined by methylation-specific polymerase chain reaction (MSP) or quantitative real-time methylation analysis (MethyLight). Colorectal cancer tissue specimens from 239 patients that had undergone surgical treatment were evaluated using immunohistochemistry (IHC) analysis for the expression of SorCS1 and correlated with clinicopathological variables and prognosis. We found that SorCS1 was hypermethylated in CRC cell lines and 67.5% (27/40) CRC tumor tissues. The loss of SorCS1 mRNA (p may be a promising prognostic factor in CRC patients.

Keywords: SorCS1, colorectal cancer, predictor, methylation
Published online: 29-Jan-2020
Year: 2020, Volume: 67, Issue: 1 Page From: 119, Page To: 128

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