Home Neoplasma 2020 Neoplasma Vol.67, No.1, p.129–136, 2020

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.67, No.1, p.129–136, 2020

Title: Loss of IGF2R indicates a poor prognosis and promotes cell proliferation and tumorigenesis in bladder cancer via AKT signaling pathway
Author: S. B. Liu, L. B. Zhou, H. F. Wang, G. Li, Q. P. Xie, B. Hu

Abstract: The insulin growth factor 2 receptor (IGF2R) belongs to insulin growth factor (IGF) pathway and has been proposed as the tumor suppressor in many cancers. However, its role in bladder cancer is unknown. In the current study, we reported that IGF2R expression was decreased in bladder cancer tissues (pd cell proliferation of bladder cancer cells in vitro and in vivo (pon level of AKT. The findings of this study indicated that IGF2R played a tumor suppressor role in bladder cancer. Downregulation IGF2R may promote tumor growth by activating AKT signaling pathway. IGF2R could be considered as a promising candidate for novel biomarker and therapeutic target for human bladder cancer.

Keywords: urinary bladder neoplasms, IGF-2 receptor, AKT signaling pathway, cell proliferation
Published online: 29-Jan-2020
Year: 2020, Volume: 67, Issue: 1 Page From: 129, Page To: 136
doi:10.4149/neo_2019_190206N108
Price: 16.80 €






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