Home Bratislava Medical Journal 2019 Bratislava Medical Journal Vol.120, No.12, p.887–893, 2019

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.120, No.12, p.887–893, 2019

Title: Effects of recurrent sevoflurane anesthesia on cognitive functions with streptozotocin induced Alzheimer disease
Author: F. D. Erkent, B. Isik, A. Kucuk, L. Ozturk, S. Neselioglu, H. T. Dogan, S. Guney, M. Arslan

Abstract: OBJECTIVE: We aimed to investigate the effects of recurrent sevoflurane anesthesia on cognitive functions in Alzheimer Disease.
MATERIALS AND METHODS: Rats were divided into 4 groups as followed: control (Group C), sevoflurane (Group S), Alzheimer’s (Group A) and Alzheimer’s + sevoflurane (Group AS)]. Cognitive functions were evaluated with Radial Arm Maze Test (RAMT). Alzheimer model was created by administering 3 mg/kg (10 μl) STZ. Sevoflurane was administered to S and AS groups. Serum samples and hippocampus tissues were analyzed.
RESULTS: In RAM test, the entry-exit data were significantly decreased in A and AS groups. After the 2nd and 3rd administration of anesthesia, the numbers were significantly decreased in Group S. Glial-fibrillary-acidic protein levels were significantly higher in AS compared to the C and S groups. The brain tissue caspase 3 activity was less than 1% in all rats in the Group C, 3 % in 2 rats and 1 % in 1 rat in the Group AS. In A and AS group, serum catalase, myeloperoxidase and ferroxidase activities were found to be higher than in the other groups and myeloperoxidase activity was higher in the AS than in the A Group. Serum native thiol, total thiol and disulfide levels were found to be significantly different in the A and AS groups.
CONCLUSION: Sevoflurane anesthesia negatively affected the cognitive functions (Tab. 5, Fig. 10, Ref. 51).

Keywords: Alzheimer, sevoflurane, Radial Arm Maze Test, rat, GFAP, Caspase-3
Published online: 18-Dec-2019
Year: 2019, Volume: 120, Issue: 12 Page From: 887, Page To: 893
doi:10.4149/BLL_2019_149


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