Home HOME Neoplasma 2020 Neoplasma Vol.67, No.2, p.410–414, 2020

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ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.67, No.2, p.410–414, 2020

Title: KRT15 overexpression predicts poor prognosis in colorectal cancer
Author: X. RAO, J. WANG, H. M. SONG, B. DENG, J. G. LI

Abstract: Keratin-15 (KRT15) is a type I keratin lacking a defined type II partner and plays a key role in maintaining cytoplasmic stability. Recently, studies have reported that KRT15 was correlated with tumor formation and progression. However, the clinical significance of KRT15 in colorectal cancer is unclear. In this study, we aimed to investigate the expression of KRT15 and its clinical significance in colorectal cancer. KRT15 expression was examined in 98 cases of colorectal cancer and matched adjacent normal tissues by quantificational real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC), respectively. Then, the clinical significance of KRT15 expression was evaluated in colorectal cancer. QRT-PCR results revealed that the mRNA levels of KRT15 in colorectal cancer tissues were significantly higher compared with those in normal tissues (p<0.0001).
The rates of KRT15 high-expression in colorectal cancer and normal tissues were 57.1% and 8.9%, respectively, and the difference was statistically significant (p overexpression predicted poor prognosis and could be used as an independent prognostic factor. These data indicate KRT15 is highly expressed in colorectal cancer and may serve as a prognostic biomarker.

Keywords: KRT15; colorectal cancer; immunohistochemistry; biomarker; prognosis
Published online: 21-Mar-2020
Year: 2020, Volume: 67, Issue: 2 Page From: 410, Page To: 414

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