Home Acta Virologica 2020 Acta Virologica Vol.64, No.1, p.20-27, 2020

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.64, No.1, p.20-27, 2020

Title: The investigation of hepatitis A virus and hepatitis E virus co-infection in humans and animals in China
Author: M. LI, H. ZHANG, L. WANG, Z. LI, J. WANG, B. XU, R. HAO, C. LIU, H. FU, H. RAO, H. ZHUANG, L. WANG

Abstract: The aim of this study was to investigate the prevalence of co-infection of hepatitis A and hepatitis E virus (HAV/HEV) in patients with acute hepatitis as well as in different animal species. A total of 46 serum samples from patients diagnosed as hepatitis A or hepatitis E and 675 fecal samples of 11 animal species were collected. The IgM class antibodies to HEV and HAV, respectively, were detected by enzyme-linked immunosorbent assay. HEV and HAV RNAs were extracted from serum and fecal samples for the nested reverse transcription polymerase chain reaction. At least 10.9% (5/46) of the patients were co-infected with both HAV and HEV. Fifteen percent (18/120) of rabbit fecal samples and 17.5% (7/40) of swine fecal samples were positive for HEV RNA, but only 1% (2/200) of ferret fecal samples were positive for HAV RNA. Our study showed that co-infection with both HAV and HEV in patients and animals is infrequent. At least in our study, we showed that ferrets may represent the potential HAV hosts.

Keywords: hepatitis A virus; hepatitis E virus; co-infection; zoonosis; prevalence
Published online: 11-Mar-2020
Year: 2020, Volume: 64, Issue: 1 Page From: 20, Page To: 27
doi:10.4149/av_2020_103


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