Home Neoplasma 2020 Neoplasma Vol.67, No.3, p.614–622, 2020

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.67, No.3, p.614–622, 2020

Title: Immediate early response protein 2 promotes the migration and invasion of hepatocellular carcinoma cells via regulating the activity of Rho GTPases
Author: X. XU, W. ZHOU, Y. CHEN, K. WU, H. WANG, J. ZHANG, Y. ZHOU, J. ZENG, J. YANG, Z. DENG, Y. ZHANG, W. SHEN

Abstract: Human immediate early response 2 (IER2) has been implicated in tumor cell motility and metastasis; however, the underlying mechanisms in hepatocellular carcinoma (HCC) metastasis remain to be clarified. In this study, we demonstrate that dysregulation of IER2 was shown in HCC clinical samples, and IER2 expression resulted in the promotion of cell migration and invasion in vitro, and HCC tumor growth and pulmonary metastasis in vivo. Moreover, we showed that IER2 expression altered assembly of the actin cytoskeleton rearrangement. Furthermore, MAPK and PI3K/Akt signaling pathways induced by IER2 were confirmed to be probably involved in regulating the activity of Rho GTPases, such as RhoA, Rac 1 and Cdc42. Collectively, our results indicated a significant role of IER2 in the HCC cell motility and metastasis through MAPK and PI3K/Akt signaling pathways to regulate the activity of Rho GTPases, thereby modulating actin cytoskeleton rearrangement, unveiling a novel mechanism of cell motility regulation induced by IER2.

Keywords: immediate early response 2; hepatocellular carcinoma cell; Rho GTPase; cell migration and invasion
Published online: 15-May-2020
Year: 2020, Volume: 67, Issue: 3 Page From: 614, Page To: 622
doi:10.4149/neo_2020_190818N781
Price: 21.60 €






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