Home Neoplasma 2020 Neoplasma Vol.67, No.3, p.668–676, 2020

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.67, No.3, p.668–676, 2020

Title: Different chromosome damage in lymphocytes of newly diagnosed gastrointestinal and breast cancer patients
Author: D. KADLCIKOVA, P. MUSILOVA, H. HRADSKA, M. PETROVOVA, I. SELINGEROVA, M. VOZDOVA, M. SVOBODA, J. RUBES

Abstract: Structural chromosome aberrations are a predictive biomarker of cancer risk. Conventional chromosome analysis widely used for these purposes detects unstable chromosome aberrations that are eliminated during cell division. Stable aberrations that may persist in the body and tend to accumulate during a lifetime can be detected by fluorescence in situ hybridization (FISH). The aim of the study was to investigate the level of chromosome damage in newly diagnosed cancer patients and control subjects by FISH. Both groups of untreated cancer patients had increased frequency of aberrant cells. However, chromosome damage affected different cytogenetic endpoints. Stable translocations and cells with complex rearrangements were elevated in breast cancer patients whereas unstable chromosome aberrations (dicentric chromosomes and acentric fragments) were elevated in gastrointestinal cancer patients. These associations observed in nonsmokers were typically not pronounced in smokers (with the exception of dicentric chromosomes in gastrointestinal patients). Exposure to tobacco smoke increased aberrations in healthy controls but not in the cancer patients. Our study suggests an association between cancer and stable chromosomal rearrangements in breast cancer patients. Unstable aberrations elevated in gastrointestinal cancer patients may be at least partly ascribed to the exposure to diagnostic X-rays.

Keywords: breast cancer, gastrointestinal cancer, risk assessment, chromosome aberration, fluorescence in situ hybridization
Published online: 15-May-2020
Year: 2020, Volume: 67, Issue: 3 Page From: 668, Page To: 676
doi:10.4149/neo_2020_190604N485
Price: 21.60 €






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