Home 
Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.3, p.211–217,2020
Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.3, p.211–217,2020
Journal info
|
||||
Select Journal
Journals
Bratislava Medical Journal 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Ekologia - Ecology Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudba 2025Webshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Bratislava Medical Journal Vol.121, No.3, p.211–217,2020 |
||
| Title: The protective effect of betanin and copper on heart and lung in end‑organ ischemia reperfusion injury | ||
| Author: K. Tural, O. Ozden, Z. Bilgi, E. Kubat, C. S Ermutlu, O. Merhan, G. Findik Guvendi, S. A. Kucuker | ||
| Abstract: OBJECTIVES: Betanin and copper sulphate have been previously indicated as beneficial agents for ischemia/reperfusion (I/R) as antioxidant compounds in various models. We investigated whether betanin and copper have any protective effects on the heart and lung against I/R injury in rats. METHODS: Spraque-Dawley rats were assigned in groups: Sham (laparotomy only), control (I/R only), betanin treatment (100 mg/kg of betanin administered intraperitoneally (i.p.) 60 minutes before I/R) and copper sulfate treatment group (0.1 mg/kg/day copper sulfate i.p. for 7 days before I/R). Ischemia was induced by clamping the aorta between the left renal artery and aortic bifurcation for 45 minutes. After 48-hour reperfusion, the rats were sacrificed and heart/lung tissues were harvested. Malondialdehyde (MDA), myeloperoxidase (MPO), interleukin 6 (IL-6) levels were determined. Apoptosis was determined via TUNEL assay. RESULTS: MDA, MPO, IL-6 levels and apoptotic cells were significantly increased in the I/R group. In both treatment groups, MDA and MPO levels were decreased. IL-6 was significantly decreased in response to betanin administration in the heart, but not in the lung; copper had no effect in either area. The numbers of apoptotic cells were significantly decreased in both treatment groups. CONCLUSION: Betanin and copper may have protective effects on I/R injury in the heart and lung in rats (Fig. 6, Ref. 39). |
||
| Keywords: ischemia reperfusion injury, betanin, copper, antiinflammation, antioxidant, rat | ||
| Published online: 26-Feb-2020 | ||
| Year: 2020, Volume: 121, Issue: 3 | Page From: 211, Page To: 217 | |
| doi:10.4149/BLL_2020_032 |
||
|
|
 download file |
|