Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.3, p.211–217,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.121, No.3, p.211–217,2020

Title: The protective effect of betanin and copper on heart and lung in end‑organ ischemia reperfusion injury
Author: K. Tural, O. Ozden, Z. Bilgi, E. Kubat, C. S Ermutlu, O. Merhan, G. Findik Guvendi, S. A. Kucuker

Abstract: OBJECTIVES: Betanin and copper sulphate have been previously indicated as beneficial agents for ischemia/reperfusion (I/R) as antioxidant compounds in various models. We investigated whether betanin and copper have any protective effects on the heart and lung against I/R injury in rats.
METHODS: Spraque-Dawley rats were assigned in groups: Sham (laparotomy only), control (I/R only), betanin treatment (100 mg/kg of betanin administered intraperitoneally (i.p.) 60 minutes before I/R) and copper sulfate treatment group (0.1 mg/kg/day copper sulfate i.p. for 7 days before I/R). Ischemia was induced by clamping the aorta between the left renal artery and aortic bifurcation for 45 minutes. After 48-hour reperfusion, the rats were sacrificed and heart/lung tissues were harvested. Malondialdehyde (MDA), myeloperoxidase (MPO), interleukin 6 (IL-6) levels were determined. Apoptosis was determined via TUNEL assay.
RESULTS: MDA, MPO, IL-6 levels and apoptotic cells were significantly increased in the I/R group. In both treatment groups, MDA and MPO levels were decreased. IL-6 was significantly decreased in response to betanin administration in the heart, but not in the lung; copper had no effect in either area. The numbers of apoptotic cells were significantly decreased in both treatment groups.
CONCLUSION: Betanin and copper may have protective effects on I/R injury in the heart and lung in rats (Fig. 6, Ref. 39).

Keywords: ischemia reperfusion injury, betanin, copper, antiinflammation, antioxidant, rat
Published online: 26-Feb-2020
Year: 2020, Volume: 121, Issue: 3 Page From: 211, Page To: 217

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