Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.3, p.230–234,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 0.859

 

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Bratislava Medical Journal Vol.121, No.3, p.230–234,2020

Title: Predictors of survival in patients with pulmonary hypertension and acute right heart failure
Author: Ambroz D, Jansa P, Kuchar J, Belohlavek J, Aschermann M, Dytrych V, Lindner J, Simkova I, Linhart A

Abstract:

OBJECTIVES: The aim of this study was to analyse survival of patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) hospitalized due to an acute right heart failure (ARHF) with emphasis on risk factors and effectiveness of treatment following current guidelines.
METHODS: We retrospectively analysed 117 hospitalizations of 70 patients (59 PAH patients; 11 CTEPH patients, mean age 53.1 ± 16.77 years, 54 % females) between 2004 and 2013.
RESULTS: 96 cases were hospitalized at cardiology wards (CW) while 21 at intensive care unit (ICU). The overall hospital mortality was 12.8 %, CW mortality was 4 %, and ICU mortality was 52.4 %. Higher risk of in-hospital mortality was associated with younger age, lower sodium levels, severe forms of PAH (heritable PAH, CTD-PAH) and need of PAH combination treatment. The one-year survival from the first ARHF hospitalization was 67.6 % (95 % CI 57.1–80 %), the two-year survival was 41.9 % (95 % CI 30.8–56.9 %). The presence of ascites was a predictor of long-term mortality.

CONCLUSIONS: Mortality in patients with PH and ARHF remains very high. Identification of its risk factors could be used as basis of risk-adapted therapy (Tab. 5, Fig. 2, Ref. 14).



Keywords: acute right hear failure, pulmonary arterial hypertension, chronic thromboembolic pulmonary hypertension, mortality
Published online: 26-Feb-2020
Year: 2020, Volume: 121, Issue: 3 Page From: 230, Page To: 235
doi:10.4149/BLL_2020_035


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