Home Acta Virologica 2020 Acta Virologica Vol.64, No.2, p.154-166, 2020

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.64, No.2, p.154-166, 2020

Title: Cell-to-cell transport in viral families: faster than usual
Author: M. Labudová

Abstract: The most frequent way of virus dissemination is through the canonical receptor-mediated pathway. However, when unfavorable conditions, such as presence of antibodies appear, the viruses use more peculiar routes of transmission to protect themselves. Here we describe most of the routes, from syncytia formation, tunneling nanotubes and filopodia, through immunological and virological synapses to actin comets formation. We describe the cell-to-cell transport in different viral families to show that this way of virus distribution is present in almost all the mammalian virus families and is not as uncommon as it was thought. The knowledge of the ways of viral transport might lead us to exploit more successful therapeutic approaches and fight the most threatening diseases.

Keywords: cell-to-cell transmission; tunneling nanotubes; viral synapses; filopodia; actin comets
Published online: 05-Apr-2020
Year: 2020, Volume: 64, Issue: 2 Page From: 154, Page To: 166
doi:10.4149/av_2020_205


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