Home HOME Neoplasma 2020 Neoplasma Vol.67, No.4, p.933–938, 2020

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.67, No.4, p.933–938, 2020

Title: The expression of CD73 on pathological B-cells is associated with shorter overall survival of patients with CLL
Author: M. Kicova, Z Michalova, M. Coma, J. Gabzdilova, K. Dedinska, T. Guman, S. Bernatova, M. Hajikova, M. Giertlova, D. Veselinyova, M. Sarissky

Abstract: CD73 is a membrane-bound enzyme that catalyzes the extracellular conversion of adenosine monophosphate to adenosine. Adenosine is thought to play a role in promoting tumor growth and survival together with suppressing the host immune responses, which contribute to the multistep process of tumorigenesis. Here, we studied the expression of this antigen in chronic lymphocytic leukemia (CLL). The expression of CD73 was analyzed by multiparametric flow cytometry on normal and pathological B-cells from peripheral blood and bone marrow samples from 71 patients with CLL. Pathological B-cells expressed significantly lower levels of CD73 than normal B-cells (p

Keywords: CD73, chronic lymphocytic leukemia, B-cells, flow cytometry, immunophenotyping, overall survival
Published online: 07-Apr-2020
Year: 2020, Volume: 67, Issue: 4 Page From: 933, Page To: 938

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