Home HOME Neoplasma 2020 Neoplasma Vol.67, No.4, p.813–824, 2020

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.67, No.4, p.813–824, 2020

Title: miR-33a-5p inhibits the growth and metastasis of melanoma cells by targeting SNAI2
Author: Z. R. Zhang, N. Yang

Abstract: MicroRNAs have been verified as critical regulators in the development of melanoma. miR-33a-5p was significantly downregulated in melanoma, however, the specific role and regulatory mechanism of miR-33a-5p in melanoma were still unclear. The present study identified that miR-33a-5p was downregulated in melanoma tissues and cells, while SNAI2 was upregulated. miR-33a-5p directly targeted SNAI2 and negatively regulated its expression in melanoma cells. Overexpression of miR-33a-5p repressed proliferation, migration, invasion, EMT and promoted apoptosis of melanoma cell in vitro, these effects were partially reversed by SNAI2 overexpression. In addition, miR-33a-5p impaired melanoma growth in vivo by inhibiting SNAI2. Mechanistically, miR-33a-5p repressed activation of the PI3K/AKT/mTOR pathway by targeting SNAI2. In conclusion, miR-33a-5p repressed the progression of melanoma by targeting SNAI2 via inactivation of the PI3K/AKT/mTOR signaling pathway, providing a potential molecular mechanism for the treatment of melanoma.

Keywords: melanoma, miR-33a-5p, SNAI2, PI3K/AKT/mTOR
Published online: 16-Apr-2020
Year: 2020, Volume: 67, Issue: 4 Page From: 813, Page To: 824

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