Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.4, p.282–286,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 0.859

 

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Bratislava Medical Journal Vol.121, No.4, p.282–286,2020

Title: Nesfatin 1: a promising biomarker predicting successful reperfusion after coronary artery bypass surgery
Author: M. Kirisci, M. M. Yardimci, A. Kocarslan, A. Sokmen, A. Doganer, H. Gunes

Abstract: OBJECTIVES: Nesfatin-1 is an antiiflammatory, antiapoptotic, and anorexigenic peptide that has many roles in cardiomyocyte metabolism and viability. Inflammation plays an important role in the pathogenesis of atherosclerosis. In this study, we aimed to evaluate the alterations in serum nesfatin-1 levels of the patients undergoing coronary artery bypass operation due to atherosclerotic coronary artery disease.
MATERIALS AND METHODS: The study included 49 patients (30 men, 19 women) undergoing coronary artery bypass surgery. Serum nesfatin-1 levels were measured from venous blood samples of the patients collected before and three months after the operation. The relationship of nesfatin-1 levels with accompanying conditions was also analyzed.

RESULTS: Nesfatin-1 levels at third month, postoperatively, were significantly higher than preoperative nesfatin-1 levels of the patients (41.94±13.90 pg/ml and 27.06±8.01pg/ml, respectively; p<0.001). Both preoperative and postoperative nesfatin-1 levels were negatively correlated with age (p<0.001). The postoperative increase in nesfatin-1 levels was significantly higher in diabetic patients than in nondiabetic patients (p<0.001).
CONCLUSION: This study revealed that serum nesfatin-1 levels increased significantly in patients undergoing coronary artery bypass operation. Nesfatin-1 level may have a role in assessing myocardial perfusion during the follow-up of these patients (Tab. 4, Fig. 4, Ref. 25).

Keywords: atherosclerosis, coronary bypass, inflammation, nesfatin-1
Published online: 01-Apr-2020
Year: 2020, Volume: 121, Issue: 4 Page From: 282, Page To: 286
doi:10.4149/BLL_2020_043


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