Home 
FOR AUTHORS Neoplasma 2020 Neoplasma Vol.67, No.5, p.947–957, 2020
FOR AUTHORS Neoplasma 2020 Neoplasma Vol.67, No.5, p.947–957, 2020
Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.67, No.5, p.947–957, 2020 |
||
| Title: Norepinephrine release may play a critical role in the Warburg effect: an integrative model of tumorigenesis | ||
| Author: P. J. Fitzgerald | ||
| Abstract: Many cancer cells share the property of carrying out markedly elevated rates of glycolysis to generate energy even in the presence of sufficient oxygen, and this is known as the Warburg effect. In recent years, there has been a resurgence of interest in the Warburg effect, as the field of oncology has amassed evidence that cellular metabolism may play a prominent role in many neoplasms. Largely in the past decade, another prominent and perhaps surprising factor has emerged in the cancer literature: the catecholamine molecules, epinephrine (adrenaline) and norepinephrine (noradrenaline), appear to play a role in tumorigenesis and metastasis. The drug propranolol, which blocks beta-adrenergic receptors, may be therapeutic in human angiosarcoma, melanoma, and ovarian cancer. The current paper synthesizes these older and more recent findings, in an attempt to unify the major factors that contribute to tumorigenesis. This paper suggests that in addition to the direct interaction of catecholamine signaling with genetic risk factors (including mutagenesis), it interacts with environmental factors such as hypertension, obesity, unhealthy dietary components, physical inactivity, substance abuse, and mental or emotional stress, to promote the Warburg effect by facilitating glucose availability through suppression of pancreatic insulin release. Further, it proposes that many cancer cells synthesize and release catecholamines to activate their own receptors in an autocrine fashion. In summary, catecholamines are an important “new” factor in cancer that may interface with both genetics and environmental factors to alter the Warburg effect and modulate tumorigenesis. |
||
| Keywords: beta-blocker, microenvironment, prazosin, pancreas, clonidine, guanfacine, genetics | ||
| Published online: 25-May-2020 | ||
| Year: 2020, Volume: 67, Issue: 5 | Page From: 947, Page To: 957 | |
| doi:10.4149/neo_2020_200422N432 |
||
|
|
 download file |
|