Home Bratislava Medical Journal 2020 Bratislava Medical Journal Vol.121, No.6, p.422–427,2020

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.121, No.6, p.422–427,2020

Title: Does the platelet‑to‑lymphocyte ratio have a prognostic effect in patients with myelodysplastic syndrome?
Author: A. S. Yikilmaz, S. Akinci , S. M. Bakanay, I. Dilek

Abstract: INTRODUCTION: Myelodysplastic syndromes (MDS) include various hematologic abnormalities characterized by chronic cytopenia due to disruption in cellular differentiation. This study aims to evaluate the prognostic value of PLR in patients with MDS.
MATERIAL AND METHODS: Clinical-laboratory findings and the results of bone marrow biopsies of MDS patients before treatment were recorded. p value of <0.05 was considered statistically significant. SPSS version 20.0 was used for statistical analysis.
RESULTS: The study included 62 patients with median follow-up time of 62.8±4.5 months and median age of 68.5 years. In 13 patients, acute leukemia was transformed. In these subjects, a PLR cut-off level of 46 was established for mortality (p=0.015). We found a significant relationship between PLR and multilineage series with the presence of dysplasia (p=0.017). The survival analysis showed a decreased survival in cases with dysplasia in two and/or more series, transformation into acute leukemia, and thrombocytopenia.
CONCLUSION: Our study demonstrated that there was a relationship between PLR and MDS with multilineage dysplasia (mld-MDS). PLR is investigated as an inflammatory finding in various hematologic malignancies. Further studies investigating the value of PLR in MDS are needed to determine whether PLR may be a marker of bone marrow dysplasia grading (Tab. 2, Fig. 4, Ref. 32).

Keywords: myelodysplastic syndromes,hematologic abnormalities, chronic cytopenia, cellular differentiation, marrow biopsy, acute leukemia, thrombocytopenia
Published online: 31-May-2020
Year: 2020, Volume: 121, Issue: 6 Page From: 422, Page To: 427
doi:10.4149/BLL_2020_068


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