Home General Physiology and Biophysics 2020 General Physiology and Biophysics Vol.39, No.3, p.203–204, 2020

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.39, No.3, p.203–204, 2020

Title: Renin-angiotensin system and SARS-CoV-2 interaction: underlying mechanisms and potential clinical implications
Author: Jaroslav Hrenak, Stefan Zorad, Fedor Simko

Abstract: Renin-angiotensin system (RAS) inhibition supposedly increases the expression of angiotensin converting enzyme 2, serving as a binding site for SARS-CoV-2. Concerns arose regarding therapy with RAS inhibition during the COVID-19 pandemic. However, the pharmacological restraining the classical RAS axis might be beneficial due to the reduction of deleterious effects of angiotensin II and enhancement of the anti-inflammatory angiotensin 1-7 pathway. Unless large controlled studies are performed, RAS inhibition remains the cornerstone therapy in populations with cardiovascular disorders.

Keywords: SARS-CoV-2, COVID-19, Angiotensin II, ACE 2, ACE-inhibitor, AT1R blocker
Published online: 10-Jun-2020
Year: 2020, Volume: 39, Issue: 3 Page From: 203, Page To: 204

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